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KMID : 0371020000330020226
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Journal of Preventive Medicine and Public Health
2000 Volume.33 No. 2 p.226 ~ p.230
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Comparison of Methods fhr the Detection of Ani-HBs for Hepatitis B Vaccination Program in Korea
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Sohn Hae-Sook
Lee Jeong-Nyeo
Urm Sang-Hwa
Lee Jong-Tae
Chun Jin-Ho
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Abstract
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Objectives : The purpose of this study was to suggest a proper method for the detection of heaptitis B surface antibody(anti-HBs) in a screening program for hepatitis B vaccination.
Methods : Sensitivity, specificity and predictive values were compared between Immunochromatographic assay (ICA) and passive hemagglutination(PHA) in 978 subjects(565 males, 413 females, 19-78 years ranging in age, mean 46.5 years old). EIA was used as a standard method for the detection of HBsAb.
Results : Sensitivity in the detection of anti-HBs of PHA and ICA was 88.7% and 94.9%, specificity was 94.3% and 96.6%, negative predictive value was 96.5% and 98.0%, and positive predictive value was 82.3% and 91.3%, respectively. False negative rate(11.3%) of PHA was higher than that(5.1%) of ICA. The higher the titer of anti-HBs in EIA was, the lower the false negative rate was. There was no false negative result in the cases with 101㎖U/β￠ or more in EIA.
Conclusion : We suggest that ICA should be the choice of screening method in the detection of anti-HBs in Hepatitis B vaccination program.
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KEYWORD
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Anti-HBs, Immunochromatographic assay, ICA, Passive hemagglutination, PHA
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